A simple and sensitive spectrofluorimetric method has been developed for the estimation of telmisartan in tablet dosage form. Telmisartan (TEL) has imidazole and biphenyl groups in its structure, which are the fluorescent groups. Based on the fluorescent groups, telmisartan produces strong fluorescence in NaOH. Fluorescence intensity was measured at 363 nm (λem) with excitation at 298 nm (λex). Linearity range was found to be 200-1200 ng/ml with mean recovery 99.78%. The correlation co-efficient was found to be 0.9992. The method was validated in terms of % RSD of repeatability (0.29), precision (intra-day variation, 0.28 to 1.45 and inter-day variation, 0.92 to 2.57 ). The limit of detection (LOD) and limit of quantification (LOQ) for telmisartan were found to be 3.89 and 11.79 ng/ml, respectively. The developed method was successfully used for the assay of telmisartan tablet formulations. The content of TEL in two marketed formulations was found to be 103.38% and 99.73% of labelled amount. The spectrofluorimetric method was found to be specific, sensitive, accurate and precise and can be used for the routine quality control testing of telmisartan in tablet dosage form.
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